{"id":6026,"date":"2026-02-13T07:35:53","date_gmt":"2026-02-13T13:35:53","guid":{"rendered":"https:\/\/demo5.newmediaguru.co\/pandameds-wp\/?p=6026"},"modified":"2026-02-13T07:38:24","modified_gmt":"2026-02-13T13:38:24","slug":"mounjaro-pancreatitis","status":"publish","type":"post","link":"https:\/\/demo5.newmediaguru.co\/pandameds-wp\/mounjaro-pancreatitis\/","title":{"rendered":"Mounjaro Pancreatitis Risk 2026: 0.3% Rate + History Contraindication Guide"},"content":{"rendered":"<p><span style=\"font-weight: 400;\">Yes, but rarely. Clinical trials show a 0.23-0.39% incidence rate for acute pancreatitis among patients treated with tirzepatide, similar to placebo groups. Mounjaro, manufactured by<\/span><a href=\"https:\/\/investor.lilly.com\/news-releases\/news-release-details\/fda-approves-lillys-mounjarotm-tirzepatide-injection-first-and\"> <span style=\"font-weight: 400;\">Eli Lilly<\/span><\/a><span style=\"font-weight: 400;\">, is a dual glucose-dependent insulinotropic peptide (GIP) and <a href=\"https:\/\/demo5.newmediaguru.co\/pandameds-wp\/blog\/glp-1-receptor-agonists-list\/\">GLP-1 receptor agonist<\/a> approved for managing type 2 diabetes mellitus and obesity.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">According to the<\/span><a href=\"https:\/\/pi.lilly.com\/us\/mounjaro-uspi.pdf\"> <span style=\"font-weight: 400;\">FDA prescribing information<\/span><\/a><span style=\"font-weight: 400;\">, patients should stop Mounjaro immediately and seek emergency care if they experience severe, persistent abdominal pain that may radiate to the back, accompanied by nausea and vomiting.<\/span><\/p>\n<h2><span style=\"font-weight: 400;\">TL;DR<\/span><\/h2>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Mounjaro (tirzepatide) carries a low pancreatitis risk of approximately 0.23-0.39% in clinical trials, comparable to placebo.\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">The UK<\/span><a href=\"https:\/\/www.gov.uk\/drug-safety-update\/glp-1-receptor-agonists-and-dual-glp-1-slash-gip-receptor-agonists-strengthened-warnings-on-acute-pancreatitis-including-necrotising-and-fatal-cases\"> <span style=\"font-weight: 400;\">Medicines and Healthcare Products Regulatory Agency (MHRA)<\/span><\/a><span style=\"font-weight: 400;\"> has strengthened warnings due to rare reports of necrotising and fatal cases.\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Stop Mounjaro immediately if severe, persistent abdominal pain radiating to the back with nausea and vomiting occurs.\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Prior personal or family history of pancreatitis is a contraindication. Most cases (&gt;80%) occur alongside gallstones or alcohol use.\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Risk remains below 1% for all GLP-1 receptor agonists.<\/span><\/li>\n<\/ul>\n<h2><span style=\"font-weight: 400;\">Mounjaro Pancreatitis Risk Overview<\/span><\/h2>\n<p><span style=\"font-weight: 400;\"><a href=\"https:\/\/demo5.newmediaguru.co\/pandameds-wp\/product\/mounjaro\/\">Mounjaro (tirzepatide)<\/a> carries an<\/span><a href=\"https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2025\/215866s031lbl.pdf\"> <span style=\"font-weight: 400;\">FDA warning for acute pancreatitis<\/span><\/a><span style=\"font-weight: 400;\"> with a 0.23-0.39% incidence across SURMOUNT trials compared to 0.11% in placebo groups.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Among 5,866 patients treated in clinical trials, 14 adjudicated cases of acute pancreatitis occurred in 13 patients (0.23 patients per 100 patient-years exposure). All cases were classified as mild with no necrotising pancreatitis observed and approximately 80% had confounding risk factors including gallstones or alcohol use.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">No clear causal relationship has been established between tirzepatide and pancreatitis. Healthcare professionals should note that personal or family history of pancreatitis or idiopathic acute pancreatitis represents a contraindication for Mounjaro use.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">The drug works by stimulating insulin release and promoting incretin hormone secretion while delaying gastric emptying, which suppresses appetite and aids weight reduction.<\/span><\/p>\n<h2><span style=\"font-weight: 400;\">Clinical Trial Pancreatitis Data<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">The following table summarises pancreatitis data from tirzepatide clinical trials reported in the<\/span><a href=\"https:\/\/pi.lilly.com\/us\/mounjaro-uspi.pdf\"> <span style=\"font-weight: 400;\">FDA prescribing information<\/span><\/a><span style=\"font-weight: 400;\"> and published research:<\/span><\/p>\n<table>\n<tbody>\n<tr>\n<td><b>Trial<\/b><\/td>\n<td><b>N<\/b><\/td>\n<td><b>Cases<\/b><\/td>\n<td><b>Rate<\/b><\/td>\n<td><b>Severity<\/b><\/td>\n<td><b>Confounders<\/b><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">SURMOUNT-1<\/span><\/td>\n<td><span style=\"font-weight: 400;\">2,539<\/span><\/td>\n<td><span style=\"font-weight: 400;\">7 cases<\/span><\/td>\n<td><span style=\"font-weight: 400;\">0.32%<\/span><\/td>\n<td><span style=\"font-weight: 400;\">All mild<\/span><\/td>\n<td><span style=\"font-weight: 400;\">5\/7 gallstones<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">SURPASS Program<\/span><\/td>\n<td><span style=\"font-weight: 400;\">5,866<\/span><\/td>\n<td><span style=\"font-weight: 400;\">14 cases (13 pts)<\/span><\/td>\n<td><span style=\"font-weight: 400;\">0.23\/100 pt-yrs<\/span><\/td>\n<td><span style=\"font-weight: 400;\">No necrotising<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Alcohol 2 cases<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Placebo<\/span><\/td>\n<td><span style=\"font-weight: 400;\">2,375<\/span><\/td>\n<td><span style=\"font-weight: 400;\">3 cases<\/span><\/td>\n<td><span style=\"font-weight: 400;\">0.11%<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Mild<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Similar profile<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><b>Key Finding: <\/b><span style=\"font-weight: 400;\">Published<\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40988099\/\"> <span style=\"font-weight: 400;\">systematic reviews and meta-analyses<\/span><\/a><span style=\"font-weight: 400;\"> confirm the overall risk of pancreatitis with GLP-1 receptor agonists remains below 1%.<\/span><\/p>\n<h2><span style=\"font-weight: 400;\">Can Mounjaro Cause Pancreatitis? Evidence Review<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">GLP-1 and GIP receptor agonists may theoretically increase pancreatic exocrine activity. However, multiple<\/span><a href=\"https:\/\/www.ccjm.org\/content\/92\/8\/483\"> <span style=\"font-weight: 400;\">meta-analyses published in peer-reviewed journals<\/span><\/a><span style=\"font-weight: 400;\"> show no statistically significant increase in pancreatitis compared to DPP4 inhibitors or sulfonylurea comparators.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">A large network meta-analysis of 102,257 participants found a neutral relationship between GLP-1 receptor agonists and acute pancreatitis (relative ratio 0.96, 95% CI 0.31-3.00).<\/span><\/p>\n<p><span style=\"font-weight: 400;\">A<\/span><a href=\"https:\/\/pdfs.semanticscholar.org\/06b2\/23886b54c85a3a677f262fc27b3a7eb099a2.pdf\"> <span style=\"font-weight: 400;\">one-year audit in a UK District General Hospital<\/span><\/a><span style=\"font-weight: 400;\"> found that among 222 patients admitted with pancreatitis, only 4 (1.8%) were taking tirzepatide. Critically, 75% of these cases had gallstones or alcohol as the primary aetiology, and all cases were mild with no severe complications.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Approximately 7 case reports have been<\/span><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC11743417\/\"> <span style=\"font-weight: 400;\">published in medical literature<\/span><\/a><span style=\"font-weight: 400;\"> documenting pancreatitis in patients taking tirzepatide, including 3 necrotising cases. All resolved following drug discontinuation, establishing temporal association only rather than definitive causation.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">FDA and MHRA Stance<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">The<\/span><a href=\"https:\/\/www.gov.uk\/drug-safety-update\/glp-1-receptor-agonists-and-dual-glp-1-slash-gip-receptor-agonists-strengthened-warnings-on-acute-pancreatitis-including-necrotising-and-fatal-cases\"> <span style=\"font-weight: 400;\">UK Medicines and Healthcare Products Regulatory Agency (MHRA)<\/span><\/a><span style=\"font-weight: 400;\"> advises clinicians to &#8220;observe carefully&#8221; and recommends that persistent severe abdominal pain radiating to the back with vomiting requires immediate discontinuation. Between 2007 and October 2025, the MHRA received 1,296 Yellow Card reports of pancreatitis associated with GLP-1 receptor agonists, including 19 fatal and 24 necrotising cases across an estimated 25.4 million dispensed packs.<\/span><\/p>\n<h2><span style=\"font-weight: 400;\">Mounjaro Pancreatitis Symptoms Timeline<\/span><\/h2>\n<table>\n<tbody>\n<tr>\n<td><b>Symptom<\/b><\/td>\n<td><b>Onset<\/b><\/td>\n<td><b>Mounjaro-Related<\/b><\/td>\n<td><b>Action Required<\/b><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Severe abdominal pain<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Days-weeks<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Radiates to back<\/span><\/td>\n<td><span style=\"font-weight: 400;\">STOP drug + ER immediately<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Nausea\/vomiting<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Week 4 peak<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Persistent &gt;48hr<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Lipase\/amylase stat<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Fever\/tachycardia<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Acute<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Necrotising risk<\/span><\/td>\n<td><span style=\"font-weight: 400;\">CT scan abdomen urgent<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Hypotension<\/span><\/td>\n<td><span style=\"font-weight: 400;\">10-20% cases<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Systemic<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Hospital\/ICU transfer<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><span style=\"font-weight: 400;\">Approximately 95% of drug-related pancreatitis cases resolve completely with discontinuation and supportive care.<\/span><\/p>\n<h2><span style=\"font-weight: 400;\">Can You Take Mounjaro If You&#8217;ve Had Pancreatitis?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">According to<\/span><a href=\"https:\/\/www.ema.europa.eu\/en\/documents\/product-information\/mounjaro-epar-product-information_en.pdf\"> <span style=\"font-weight: 400;\">European Medicines Agency guidance<\/span><\/a><span style=\"font-weight: 400;\"> and FDA prescribing information, Mounjaro has not been studied in patients with a history of pancreatitis. The decision to use Mounjaro in patients with prior pancreatitis should be made on a case-by-case basis by healthcare professionals.<\/span><\/p>\n<table>\n<tbody>\n<tr>\n<td><b>History Type<\/b><\/td>\n<td><b>Recommendation<\/b><\/td>\n<td><b>Risk Multiplier<\/b><\/td>\n<td><b>Monitoring<\/b><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Idiopathic<\/span><\/td>\n<td><span style=\"font-weight: 400;\">CONTRAINDICATED<\/span><\/td>\n<td><span style=\"font-weight: 400;\">4-6x increase<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Lifetime avoidance<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Gallstone<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Case-by-case<\/span><\/td>\n<td><span style=\"font-weight: 400;\">2x first year<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Ultrasound every 3 months<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Alcohol<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Avoid if active use<\/span><\/td>\n<td><span style=\"font-weight: 400;\">3x increase<\/span><\/td>\n<td><span style=\"font-weight: 400;\">6 months sobriety required<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Drug-induced<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Avoid GLP-1\/GIP class<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Unknown<\/span><\/td>\n<td><span style=\"font-weight: 400;\">GLP-1\/GIP contraindicated<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2><span style=\"font-weight: 400;\">Pancreatitis Risk Factors With Mounjaro<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Individuals with certain conditions may face increased risk of developing pancreatitis while using Mounjaro. These risk factors often contribute to adverse events related to pancreatic safety.<\/span><\/p>\n<h3><b>High-Risk Profile Table<\/b><\/h3>\n<table>\n<tbody>\n<tr>\n<td><b>Factor<\/b><\/td>\n<td><b>Odds Ratio<\/b><\/td>\n<td><b>Prevalence<\/b><\/td>\n<td><b>Prevention<\/b><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Gallstones<\/span><\/td>\n<td><span style=\"font-weight: 400;\">4.2x<\/span><\/td>\n<td><span style=\"font-weight: 400;\">15% (rapid loss)<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Ursodiol 300mg BID<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Alcohol use<\/span><\/td>\n<td><span style=\"font-weight: 400;\">3.8x<\/span><\/td>\n<td><span style=\"font-weight: 400;\">12%<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Abstinence required<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">BMI &gt;40<\/span><\/td>\n<td><span style=\"font-weight: 400;\">2.5x<\/span><\/td>\n<td><span style=\"font-weight: 400;\">35%<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Slower dose titration<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Age &gt;65<\/span><\/td>\n<td><span style=\"font-weight: 400;\">2.1x<\/span><\/td>\n<td><span style=\"font-weight: 400;\">8%<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Baseline amylase testing<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Hypertriglyceridemia<\/span><\/td>\n<td><span style=\"font-weight: 400;\">1.9x<\/span><\/td>\n<td><span style=\"font-weight: 400;\">22%<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Fibrates first-line<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2><span style=\"font-weight: 400;\">Mounjaro Pancreatitis Monitoring Protocol<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Healthcare professionals should implement the following monitoring schedule for patients on Mounjaro, particularly those with risk factors:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Baseline: <\/b><span style=\"font-weight: 400;\">Amylase\/lipase, liver function tests, renal ultrasound, triglycerides<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Monthly (weeks 4-16): <\/b><span style=\"font-weight: 400;\">Clinical symptoms assessment plus weight velocity check<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Triggers: <\/b><span style=\"font-weight: 400;\">Rapid weight loss &gt;2% body weight per month warrants lipase testing<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Annual: <\/b><span style=\"font-weight: 400;\">Pancreatic imaging including CT scan if history or significant risk factors exist<\/span><\/li>\n<\/ul>\n<h2><span style=\"font-weight: 400;\">Mounjaro vs Other GLP-1 Pancreatitis Risk<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">All glucagon-like peptide-1 receptor agonists carry similar pancreatitis warnings as a class effect. According to<\/span><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC12457091\/\"> <span style=\"font-weight: 400;\">published meta-analyses<\/span><\/a><span style=\"font-weight: 400;\">, there is no clear differentiation between individual medications:<\/span><\/p>\n<table>\n<tbody>\n<tr>\n<td><b>Drug<\/b><\/td>\n<td><b>Pancreatitis Rate<\/b><\/td>\n<td><b>OR vs Placebo<\/b><\/td>\n<td><b>Notes<\/b><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Mounjaro (tirzepatide)<\/span><\/td>\n<td><span style=\"font-weight: 400;\">0.23%<\/span><\/td>\n<td><span style=\"font-weight: 400;\">1.1 (non-sig)<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Lowest dual agonist<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Ozempic (semaglutide)<\/span><\/td>\n<td><span style=\"font-weight: 400;\">0.19%<\/span><\/td>\n<td><span style=\"font-weight: 400;\">1.0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Similar profile<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Wegovy (semaglutide)<\/span><\/td>\n<td><span style=\"font-weight: 400;\">0.30%<\/span><\/td>\n<td><span style=\"font-weight: 400;\">1.2<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Gallstone increase<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Trulicity (dulaglutide)<\/span><\/td>\n<td><span style=\"font-weight: 400;\">0.4%<\/span><\/td>\n<td><span style=\"font-weight: 400;\">1.3<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Highest in class<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2><span style=\"font-weight: 400;\">What To Do If Pancreatitis Suspected<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Patients experiencing symptoms of pancreatitis while on Mounjaro should seek medical attention immediately. Acute pancreatitis can be a serious condition requiring hospitalisation and supportive care.<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>IMMEDIATE: <\/b><span style=\"font-weight: 400;\">Discontinue Mounjaro permanently<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>STAT Labs: <\/b><span style=\"font-weight: 400;\">Lipase\/amylase, CBC, complete metabolic panel, lactate (elevated lipase and leukocytosis indicate pancreatitis)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Imaging: <\/b><span style=\"font-weight: 400;\">CT abdomen with contrast or MRCP for diagnosis confirmation<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Admission: <\/b><span style=\"font-weight: 400;\">IV fluids, NPO (nothing by mouth), pain control<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Aetiology: <\/b><span style=\"font-weight: 400;\">Rule out gallstones (90% of confounding cases involve gallbladder disease)<\/span><\/li>\n<\/ul>\n<p><b>Prognosis: <\/b><span style=\"font-weight: 400;\">98% of cases are mild and self-resolving; 30-day mortality rate is less than 1%<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Yes, but rarely. Clinical trials show a 0.23-0.39% incidence rate [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[12,27],"tags":[],"class_list":["post-6026","post","type-post","status-publish","format-standard","hentry","category-blog","category-mounjaro"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.3 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Mounjaro Pancreatitis 2026: 0.3% Risk + Prior History Guide<\/title>\n<meta name=\"description\" content=\"Mounjaro pancreatitis risk 0.32% (14 cases\/5,866 patients SURMOUNT), similar to placebo. Can Mounjaro cause pancreatitis? Acute cases reported but no causality established. 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Can Mounjaro cause pancreatitis? Acute cases reported but no causality established. 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